Instructions For Author

Comprehensive guidance for toxicology manuscript preparation.

Journal of Experimental and Clinical Toxicology publishes original research, clinical reports, systematic reviews, and methods papers addressing toxic agents, exposure pathways, and safety outcomes.

Manuscripts should demonstrate relevance to experimental or clinical toxicology and clear reporting of exposure and endpoints.

• Title page with author affiliations and corresponding author details
• Structured abstract with objectives, methods, results, and conclusions
• Introduction outlining toxicology context and knowledge gap
• Methods detailing exposure, dose, and endpoints
• Results with clear statistical reporting
• Discussion addressing implications, limitations, and safety relevance
• Conclusion summarizing toxicology impact

• Use clear headings and consistent terminology
• Define chemical names and abbreviations at first use
• Provide units for all exposure and outcome measures
• Submit tables in editable format with descriptive titles
• Include figure legends with sample sizes and methods

• Describe dose, duration, and route of exposure
• Report chemical identity and purity
• Provide species, strain, sex, and age details
• Report control conditions and comparators
• Describe biomarker assays and validation
• Document adverse events or safety signals

• Provide ethics approval and informed consent statements
• Include data availability statements and repository links
• Describe access restrictions for sensitive data
• Disclose conflicts of interest and funding sources
• Register clinical trials when applicable

• Ensure references are complete and consistent
• Include DOIs when available
• Match in text citations with reference list
• Use standard citation formats

Confirm these items before submission.

• Abstract includes primary outcomes and exposure details
• Chemical identifiers and CAS numbers included
• Assay methods and validation described
• Sample size and power rationale provided
• Statistical methods and software listed
• Data repository links or access statements included
• Conflicts of interest disclosed
• Cover letter confirms originality and scope fit
• All authors approve final submission
• Supplementary files labeled clearly

For questions about scope, data reporting, or compliance, contact the editorial team for guidance before submission.

Use this checklist to ensure complete reporting for toxicology studies.

• Define the toxic agent and chemical identity clearly
• Describe exposure route, duration, and dose levels
• Provide formulation details and purity information
• Report organism or population characteristics
• Describe inclusion and exclusion criteria
• Provide sample size rationale and power calculations
• Specify primary and secondary endpoints
• Describe analytical methods and assay validation
• Include control conditions and comparators
• Report randomization and blinding procedures
• Provide statistical methods and software versions
• Document handling of missing data
• Report adverse events and safety signals
• Provide data availability and repository links
• Describe limitations and generalizability
• Report ethical approvals and consent statements
• Include quality control and calibration steps
• Clarify exposure metrics and units
• Provide raw data summaries where possible
• Discuss relevance to clinical or regulatory decisions
• Provide uncertainty estimates or confidence intervals
• State any protocol deviations
• Report recovery or reversibility outcomes
• Include negative findings transparently

Clear biomarker and exposure documentation improves clinical relevance.

• Describe sampling matrix and collection timing
• Provide detection limits and assay sensitivity
• Report quality control procedures for biomarkers
• Describe biomarker normalization and scaling
• Explain clinical interpretation of biomarker changes
• Provide reference ranges when available
• Document storage and handling conditions
• Describe metabolite or degradation products
• Explain rationale for biomarker selection
• Include validation against established methods
• Report inter assay and intra assay variability
• Provide data on exposure variability
• Discuss confounding factors and adjustments
• Report co exposure assessments
• Note assay limitations or interference

Compliance details support trust and regulatory relevance.

• List ethics committee approvals and protocol numbers
• Describe informed consent or waiver process
• Provide trial registration identifiers if applicable
• Disclose sponsor influence on study design
• Report conflicts of interest and funding sources
• State adherence to GLP or other standards
• Describe animal welfare considerations
• Provide clinical safety monitoring procedures
• Explain data access restrictions
• Include statements on data integrity and transparency

Confirm all submission components are complete.

• Title page with corresponding author details
• Structured abstract and keywords
• Main text with consistent formatting
• Tables and figures labeled clearly
• Supplementary files referenced in text
• Cover letter confirming scope fit
• Author contribution statements
• Conflict of interest and funding statements
• Data availability statement
• Ethics approval documentation
• Suggested reviewers if required

Transparent statistics support reproducibility and interpretation.

• Define primary and secondary endpoints clearly
• Report effect sizes and confidence intervals
• Describe model assumptions and diagnostics
• Provide details on covariates and adjustments
• Describe multiple comparison corrections
• Explain rationale for statistical tests used
• Report exact p values when possible
• Include sensitivity or subgroup analyses
• Describe handling of missing or censored data
• Report statistical software and version details
• Provide pre registration details when available
• Explain any interim analyses or stopping rules
• Document data transformations or scaling
• Report variability measures for outcomes
• Include correlation or regression diagnostics
• Describe sample size or power calculations
• Provide confidence intervals for key estimates
• Explain model selection criteria
• Clarify random effects or hierarchical models
• Include validation or cross validation steps

Safety reporting strengthens clinical translation.

• Describe adverse event definitions and grading
• Report frequency and severity of events
• Provide timelines for adverse events
• Describe safety monitoring procedures
• Explain discontinuation or dose adjustments
• Report serious adverse events separately
• Provide risk mitigation strategies
• Include monitoring for cumulative toxicity
• Describe follow up for delayed effects
• Provide clinical management details
• Explain reporting to oversight bodies
• Include safety signals and thresholds
• Discuss implications for patient counseling
• Provide guidance for clinical monitoring
• Report safety outcomes for subgroups

Toxicology manuscripts should emphasize clarity in exposure characterization, analytical methods, and outcome measures. Provide consistent terminology for chemicals, biological systems, and endpoints so reviewers can compare results across studies and assess relevance to human or environmental health.

For experimental studies, describe model selection, dose justification, and exposure duration in detail. For clinical or observational studies, provide diagnostic criteria, population characteristics, and data sources that allow readers to understand applicability to real world safety decisions.

High quality figures and tables are essential for toxicology reporting. Use clear labels, include units and detection limits, and explain any normalization or scaling. Provide legends that describe sampling conditions, assay platforms, and statistical approaches.

Data transparency strengthens trust in toxicology evidence. Share repositories, accession numbers, and analytic scripts when possible. If data are restricted, describe the access pathway and the conditions for reuse.

When applicable, connect findings to regulatory guidance, clinical monitoring strategies, or exposure mitigation. This translation helps readers understand how toxicology evidence informs public health decisions.

Complete these checks before uploading your final files.

• Confirm figure resolution meets journal standards
• Verify tables match results and units
• Check that abbreviations are defined
• Ensure references include DOIs when available
• Confirm ethics statements are in the manuscript
• Provide trial registration details where applicable
• Review data availability statements for accuracy
• Confirm all coauthors approve the submission
• Check that supplementary files are referenced
• Include a concise cover letter summary

These reminders help complete the submission package with confidence.

• Confirm that all figures are cited in the text
• Check that tables include units and definitions
• Ensure the abstract matches the main results
• Verify that keywords align with study focus
• Confirm that ethics approvals are stated clearly
• Provide funding and sponsor roles in the acknowledgements
• Ensure data access links are active
• Review formatting for consistency across sections
• Confirm that statistical methods are described
• Check that limitations are discussed transparently
• Include statement on conflicts of interest
• Verify that consent procedures are documented
• Ensure the cover letter explains scope fit