Call for Papers

Submit toxicology research that clarifies exposure risks, mechanisms, and clinical outcomes.

Journal of Experimental and Clinical Toxicology publishes research that addresses toxic agents, exposure pathways, and health outcomes across experimental and clinical settings.

We prioritize studies that connect mechanistic findings with clinically meaningful endpoints, regulatory relevance, or risk mitigation strategies.

• Chemical exposure assessment and biomonitoring
• Drug induced toxicity and adverse event mechanisms
• Environmental and occupational toxicology
• In vitro, in vivo, and alternative testing models
• Toxicogenomics and systems toxicology
• Mixture toxicity and cumulative risk assessment
• Nanomaterials and emerging contaminants
• Biomarkers of exposure, effect, and susceptibility
• Poisoning epidemiology and clinical case studies
• Risk communication and regulatory toxicology
• Computational toxicology and predictive modeling
• Safety pharmacology and post market surveillance

• Short communications reporting high impact findings
• Perspectives on regulatory science and safety policy
• Data resources that enable toxicology research
• Consensus statements or guidance documents

Use this checklist to improve transparency, reproducibility, and clinical translation.

• Define exposure agent, formulation, and purity
• Describe dose, duration, and route of exposure
• Report control conditions and comparators
• Specify species, strain, sex, and age where relevant
• Describe sample size rationale and power considerations
• Report primary endpoints and measurement methods
• Provide statistical methods and data handling steps
• Include ethics approvals and consent statements
• Report adverse events and safety signals
• Disclose funding sources and conflicts of interest
• Provide data availability statements and repository links
• Describe limitations and generalizability

We prioritize submissions that clarify how toxicological evidence informs clinical practice, regulatory decisions, and public health interventions.

Authors should explain how findings advance safety standards, risk mitigation, or therapeutic decision making.

• Link mechanistic findings to clinical outcomes
• Discuss relevance to exposure limits or guidelines
• Highlight implications for vulnerable populations
• Provide context for occupational or environmental risk

Manuscripts are screened for scope, ethics, and reporting quality before single blind peer review.

Confirm these items to align with scope and accelerate review.

• Clarify study objectives and toxicological hypothesis
• Provide exposure metrics and units in the abstract
• Include validated assays or reference standards
• Report quality control procedures and calibration
• Document inclusion and exclusion criteria
• Describe sample handling and storage conditions
• Report dose response or threshold analyses
• Explain statistical modeling choices
• Include data sharing or access pathways
• Provide regulatory context when applicable
• State relevance to clinical or environmental safety
• Outline limitations and future research needs
• Confirm manuscript type and word count
• Provide graphical abstracts if available
• List author contributions and approvals
• Confirm no overlapping submissions

For questions about scope, data reporting, or compliance, contact the editorial team for guidance before submission.

Use this checklist to make exposure methods clear for reviewers and regulators.

• Report chemical name, CAS number, and formulation or vehicle details
• Describe exposure route, duration, and dosing schedule
• Provide concentration units and conversion methods
• Include dose range and rationale for selected levels
• Describe exposure monitoring and compliance checks
• Report sample collection timing and matrix
• Document environmental conditions during exposure
• Note co exposures or background levels
• Describe dose response modeling approach
• Clarify positive and negative control conditions
• Provide toxicokinetic sampling windows
• List analytical methods used for exposure measurement
• Include detection limits and calibration procedures
• State storage conditions for exposure samples
• Report recovery rates and quality control metrics
• Describe handling of values below detection limit
• Provide internal or external reference standards
• Explain any adjustments for body weight or surface area
• Specify exposure frequency and cumulative dose
• Report deviations from planned exposure protocol
• State any co administered substances or medications
• Describe randomization procedures for exposure groups
• Report blinding procedures when applicable
• Include dose normalization or scaling decisions

Mechanistic detail strengthens translational impact for toxicology studies.

• Describe target pathways and biological rationale
• Report omics platforms, coverage, and normalization steps
• Provide validation using orthogonal assays
• Discuss relevance to known toxicity pathways
• Clarify biomarker selection and clinical interpretation
• Provide pathway enrichment methods and thresholds
• Include replication or independent cohort validation
• Report sensitivity analyses for key mechanistic claims
• Explain how mechanisms inform risk assessment
• Provide limitations of mechanistic inference
• State potential species differences in mechanisms
• Report reversibility or recovery findings
• Link mechanistic findings to observable outcomes
• Note uncertainty in pathway mapping
• Provide access to omics data repositories
• Describe batch correction and quality checks
• Discuss off target effects or alternative explanations
• Highlight implications for safer chemical design
• Report negative findings transparently
• Describe adverse outcome pathway alignment

Translate toxicology findings to clinical or policy decisions whenever possible.

• Explain relevance to regulatory thresholds or guidelines
• Describe implications for occupational exposure limits
• Discuss vulnerable populations or sensitive subgroups
• Clarify potential clinical monitoring strategies
• Provide evidence for mitigation or risk reduction
• Report uncertainty and confidence in risk estimates
• Discuss how findings inform pharmacovigilance
• Highlight implications for product safety evaluation
• Note limitations for real world exposure scenarios
• Include recommendations for future safety studies
• Explain how evidence may inform labeling decisions
• Report clinical outcomes for human studies
• Describe translation to public health messaging
• Discuss external validity across populations
• Provide guidance for follow up studies

Strong experimental design improves trust in toxicology findings.

• Describe randomization and allocation methods clearly
• Include blinding procedures for outcome assessment
• Provide justification for sample size and effect size
• Report inclusion and exclusion criteria for all groups
• Explain housing or environmental conditions for animal studies
• Document batch effects and how they were controlled
• Provide details on replicate counts and independent repeats
• Explain statistical corrections for multiple comparisons
• Report confidence intervals alongside p values
• Describe criteria for outlier handling and exclusions
• Provide raw data summaries or distributions
• Explain how missing data were addressed
• Describe any protocol deviations and their impact
• Include method validation or inter laboratory comparisons
• Report instrumentation models and calibration settings
• Provide quality assurance metrics for assays
• List software versions used for analysis