1. Scope and Fit Screening

Before formatting, confirm that your manuscript directly addresses thrombosis prevention, diagnosis, treatment, outcomes, service quality, or translational relevance. We prioritize submissions that help clinicians and policy teams make better evidence based decisions in real care settings.

Include a fit statement in your cover letter that names the care problem, study contribution, and intended impact on thrombosis management. Manuscripts with weak fit framing are often delayed at triage even when scientific methods are acceptable.

• State clinical context and target population clearly.
• Define the decision question your study answers.
• Avoid broad claims without implementation relevance.

2. Manuscript File Set

Submit a complete file package to reduce administrative back and forth. At minimum, include main manuscript, title page, figures, tables, supplementary files when applicable, and declarations for ethics, conflicts, and data availability.

Ensure the corresponding author email, affiliations, and author order are final before upload. Metadata inconsistencies are a frequent source of technical hold notifications during initial checks.

4. Ethics, Consent, and Regulatory Reporting

Human subject manuscripts must include ethics committee details, approval references, and participant consent approach. If consent was waived, provide explicit oversight rationale. For retrospective record studies, clarify de identification controls and institutional data governance status.

Manuscripts with incomplete ethics language may be paused until clarification is provided. If your study spans jurisdictions, include a concise compliance note explaining how regional requirements were satisfied.

When vulnerable populations are involved, describe additional safeguards, monitoring process, and risk mitigation controls clearly.

5. Statistical and Analytical Expectations

Report statistical methods in enough detail for external interpretation. Include effect size context where appropriate and avoid reliance on isolated threshold statements. Clarify model assumptions, missing data strategy, and any sensitivity analyses used to test stability.

For subgroup analyses, declare whether these were predefined or exploratory. If multiple outcomes are tested, explain how interpretation risk from multiplicity is handled. Keep claims proportionate to available data and study design limits.

9. Advanced Reporting Quality Controls

For complex thrombosis manuscripts, include reporting controls that allow reviewers to trace each endpoint from protocol intent to analytic output. Clearly define primary outcome timing windows, censoring logic, and handling of therapy crossover. If post hoc analyses are performed, label them explicitly and explain why they were needed. Review quality improves when analytic decisions are transparent and chronologically coherent.

When using multivariable models, report variable selection rationale and assumptions in plain language. For machine learning or predictive workflows, include calibration and external validity context, not only discrimination metrics. Clinical readers need interpretability as much as statistical performance.

If subgroup findings drive conclusions, present effect direction consistency and uncertainty limits. Avoid overstatement where confidence intervals are wide or sample sizes are limited. This discipline protects manuscript credibility and reduces major revision risk.

10. Final Submission Governance Routine

Before upload, run a formal internal quality check led by the corresponding author. Confirm author order, declaration alignment, table and figure numbering, and final reference integrity. Ensure supplementary files are cited correctly and that all critical methodology details remain in the main manuscript rather than only appendices.

Establish one internal review checklist record for each submission. This simple governance step improves team accountability and reduces recurrent errors across future manuscripts. Teams that implement this routine often report faster editorial progression and fewer technical correction requests.