Submit Your Pain Pathophysiology Research
Join leading pain researchers publishing mechanistic studies, biomarker discoveries, and molecular pathway analyses in an open-access journal committed to advancing our understanding of pain mechanisms
Two Convenient Submission Methods
Choose the submission method that works best for your research workflow. Both options provide secure, efficient manuscript handling with full tracking capabilities.
ManuscriptZone Portal
Our comprehensive manuscript management system designed for seamless submission and tracking of your pain pathophysiology research.
- Auto-save functionality protects your work
- Real-time submission status tracking
- Direct access to reviewer comments
- Guided workflow for complex submissions
- Secure document management
- Revision tracking and version control
Best for: Complete manuscript management from submission through publication, especially for studies with multiple authors or complex supplementary materials.
Submit via ManuscriptZoneQuick Submission Form
A streamlined submission process for straightforward manuscripts, perfect for rapid communication of your pain mechanism discoveries.
- No account creation required
- Simple, intuitive interface
- Fast submission process
- Immediate confirmation
- Ideal for single-author papers
- Mobile-friendly design
Best for: Quick submissions of short communications, letters, or straightforward research articles without extensive supplementary materials.
Use Quick Submission FormNew to our journal? We recommend starting with the ManuscriptZone Portal for the most comprehensive submission experience. First-time users receive guided assistance through each step of the process.
Pain Pathophysiology Research We Publish
We welcome mechanistic studies that advance our understanding of pain pathways, molecular targets, and disease mechanisms. Our expert reviewers specialize in pain neurobiology, molecular mechanisms, and translational pain research.
Original Research Articles
Comprehensive studies investigating molecular mechanisms of pain, nociceptor signaling pathways, neuroinflammatory processes, and cellular mechanisms underlying chronic pain conditions.
Biomarker Discovery Studies
Research identifying and validating molecular biomarkers for pain conditions, including proteomic analyses, genetic markers, and novel diagnostic indicators for pain pathophysiology.
Mechanistic Reviews
Comprehensive reviews synthesizing current understanding of pain mechanisms, molecular pathways, cellular processes, and emerging therapeutic targets in pain pathophysiology.
Disease Model Studies
Research utilizing animal models, cellular models, or in vitro systems to investigate pain mechanisms, test therapeutic interventions, or validate molecular targets.
Molecular Pathway Analyses
Studies elucidating signaling cascades, gene expression patterns, epigenetic modifications, and molecular networks involved in pain initiation, maintenance, or resolution.
Rapid Communications
Brief reports of significant preliminary findings, novel methodologies, or breakthrough discoveries in pain mechanism research requiring rapid dissemination.
Methods & Protocols
Detailed descriptions of novel experimental techniques, analytical methods, or protocols for investigating pain mechanisms, molecular targets, or cellular processes.
Translational Studies
Research bridging basic pain mechanism discoveries with clinical applications, including target validation, proof-of-concept studies, and mechanistic clinical investigations.
Pre-Submission Checklist
Ensure your pain pathophysiology manuscript is ready for submission by verifying these essential components. Complete submissions receive faster editorial screening and review assignment.
Manuscript File: Complete manuscript in Word (.docx) or LaTeX format with all sections properly structured and referenced
High-Quality Figures: All figures prepared at publication quality (TIFF or EPS format, minimum 300 DPI) with clear labels and legends
Ethics Documentation: IRB/IACUC approval letters for human or animal studies, including protocol numbers and approval dates
Author Agreements: All co-authors have reviewed and approved the manuscript for submission and agreed to authorship order
Competing Interests: Declaration of any financial, professional, or personal relationships that could influence the research
Data Availability: Statement describing how readers can access underlying data, protocols, and materials used in the study
Reporting Guidelines: Adherence to field-specific standards (ARRIVE for animal studies, CONSORT for trials, STROBE for observational studies)
Cover Letter: Letter to the editor highlighting the significance of your findings and their contribution to pain mechanism understanding
Manuscript Preparation Tip: For pain mechanism studies, clearly describe your experimental model, molecular techniques, and analytical methods. Include detailed methodology for reproducibility and specify all reagents, antibodies, and equipment used.
Peer Review Timeline
We maintain transparent, predictable timelines to help you plan your research dissemination. Our expert pain pathophysiology reviewers provide constructive, detailed feedback to strengthen your manuscript.
Submission Received
Your manuscript enters our system and undergoes automated plagiarism screening using iThenticate. You receive immediate confirmation with a manuscript tracking number.
Day 0Editorial Screening
Our editorial team reviews your manuscript for scope, quality, and adherence to submission guidelines. Papers focused on pain mechanisms and molecular pathophysiology receive priority consideration.
Days 1-3Reviewer Assignment
We select expert reviewers with specific expertise in your research area (e.g., nociceptor biology, neuroinflammation, molecular pain mechanisms) to ensure knowledgeable evaluation.
Days 4-7Peer Review
Typically 2-3 reviewers with expertise in pain pathophysiology evaluate your manuscript for scientific rigor, methodological soundness, and contribution to the field.
Days 8-28Editorial Decision
Based on reviewer recommendations, the editor makes a decision: Accept, Minor Revisions, Major Revisions, or Reject. You receive detailed reviewer comments and editorial guidance.
Days 29-35Revision Submission
If revisions are requested, you submit your revised manuscript with a point-by-point response to reviewer comments. We recommend addressing all concerns thoroughly.
Author timelineRe-review (if needed)
For major revisions, manuscripts return to reviewers to verify that concerns have been adequately addressed. Minor revisions are typically evaluated by the editor only.
Days 36-50Final Acceptance
Once all requirements are met, your manuscript is accepted for publication. You receive a formal acceptance letter and publication timeline.
Day 51-60Production & Publication
Your manuscript undergoes copyediting, formatting, and final proofing. Upon your approval, it's published online with a DOI and becomes immediately accessible worldwide.
Days 61-70Average Time to Publication: 60-70 days from submission to online publication. Fast-track review is available for breakthrough discoveries in pain mechanisms or urgent public health relevance.
Why Pain Researchers Choose Our Journal
We provide the infrastructure, expertise, and global reach to ensure your pain pathophysiology research achieves maximum impact and visibility within the scientific community.
Expert Pain Reviewers
Manuscripts evaluated by specialists in pain neurobiology, molecular mechanisms, and translational pain research
Global Indexing
Published articles indexed in Google Scholar for maximum discoverability
Fast Decisions
Average time to first decision: 21 days. Fast-track review available for significant mechanistic discoveries
Open Access Impact
Immediate worldwide accessibility ensures your pain mechanism research reaches the broadest possible audience
Committed to COPE publication ethics, research integrity, and transparent review practices
APC Support
Waivers and discounts available for researchers from low-income countries and unfunded studies
Submission Guidelines for Pain Mechanism Studies
Manuscript Structure
Pain pathophysiology manuscripts should follow a clear structure that facilitates understanding of your mechanistic findings:
Title: Concise and specific, clearly indicating the pain mechanism or molecular pathway investigated (e.g., "TRPV1 Channel Sensitization Mediates Inflammatory Pain Through PKC-Dependent Phosphorylation")
Abstract: Structured format (Background, Methods, Results, Conclusions) limited to 300 words. Clearly state the mechanistic question, experimental approach, key findings, and implications for pain understanding.
Introduction: Establish the current understanding of the pain mechanism, identify knowledge gaps, and clearly state your research objectives and hypotheses.
Methods: Provide sufficient detail for reproducibility. Include animal models used (strain, age, sex), molecular techniques (antibodies, primers, reagents), analytical methods, and statistical approaches. Follow ARRIVE guidelines for animal studies.
Results: Present findings logically, using figures and tables to illustrate key mechanistic data. Include appropriate controls and statistical analyses. Avoid interpretation in this section.
Discussion: Interpret findings in the context of existing pain mechanism literature, discuss limitations, propose mechanistic models, and suggest future research directions.
Figure and Data Requirements
High-quality visual presentation of mechanistic data is essential for pain pathophysiology research:
- Figures: TIFF or EPS format, minimum 300 DPI resolution
- Western blots: Include molecular weight markers and loading controls
- Immunofluorescence: Provide scale bars and specify magnification
- Behavioral data: Show individual data points, not just means
- Statistical analyses: Specify tests used, sample sizes, and p-values
- Molecular diagrams: Use standard pathway notation and nomenclature
Ethics and Reporting
All pain mechanism research must meet rigorous ethical standards:
- Animal studies: IACUC approval required, follow ARRIVE guidelines
- Human samples: IRB approval and informed consent documentation
- Cell lines: Authentication and mycoplasma testing verification
- Antibodies: Specify catalog numbers, dilutions, and validation
- Statistical methods: Pre-specified analyses, appropriate sample sizes
- Data availability: Raw data deposition in appropriate repositories
Need Assistance?
Our editorial team is here to help with any questions about manuscript preparation, submission requirements, or the peer review process. Contact us at [email protected]
