Extracellular Fluid

Extracellular fluid (ECF) is a component of bodily fluids outside of cells in all multicellular organisms. It makes up about one-third of an individual's total body water and provides electrolytes, such as sodium and chloride, for the body's cells and organs to properly function. ECF is important for transporting substances such as hormones, nutrients, and waste products throughout the body. Disorders associated with ECF are often due to electrolyte abnormalities, ranging from hyponatremia to hypernatremia. ECF is also used in medical treatments, such as dialysis and plasmapheresis, for the removal and replacement of substances in the body. With a better understanding of ECF, it is possible to develop treatments for many disorders related to this important component.