Overview
Peptides are short chains of amino acids joined by peptide bonds, intermediate in size between single amino acids and full proteins, and they serve as signalling molecules, structural elements, and the building blocks of larger polypeptides. Their defined sequences and folding determine biological activity, and their synthesis, modification, and analysis are central to chemistry, biology, and drug development. Because peptides can be designed to bind specific targets and modulate cellular processes, they are widely pursued as therapeutic and diagnostic agents. Research in this area examines methods for peptide synthesis, including solid-phase synthesis carried out in aqueous solution with reusable supports and strategies for protecting reactive side chains such as lysine. Studies also investigate peptides designed to block hydrophobic interactions and inhibit amyloid formation, and antimicrobial and antifungal peptides evaluated through computational inhibition of essential microbial proteins. A substantial body of related work applies proteomic and mass-spectrometry techniques, including stable-isotope labelling, ion-current-based quantification, and affinity purification, to characterise peptides and proteins, their responses to drug treatment, and their roles in disease. By connecting synthetic chemistry, structural design, and proteomic analysis, peptide research underpins the development of therapeutic proteins, the modulation of cell signalling, and the discovery and characterisation of biologically active molecules.
Research published in this journal
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
Quantitative Proteomics Using 15N SILAC Mouse
Peptide Synthesis in Aqueous Solution With a Reusable Solid Phase
Human Proteome Project and Current Bioinformatics Status in Disease Diagnosis and Treatment
Raising HLA-E-Restricted HIV-1-Specific Immune Responses Through T Cell Vaccination: A Hypothesis
Cardiorenal Signaling Pathways in Heart Failure: Good and Bad News
Determination of the Proteomic Response to Lapatinib Treatment using a Comprehensive and Reproducible Ion-Current-Based Proteomics Strategy
Protection Side Chain of Lysine by Host-Affinity Molecules during Solid Phase Peptide Synthesis in Aqueous Phase
In Silico Inhibition of Essential Candida albicans Proteins by Arenicin, a Marine Antifungal Peptide
Optimization and ZSPORE Analysis of Affinity Purification Coupled with Tandem Mass Spectrometry in Mammalian Cells
Shotgun Label-Free Proteomic Analyses of the Oyster Parasite Perkinsus Marinus
Proteomic and Genomic Techniques in Medical Research: Applications in Cancer, Diagnostics, and Personalized Medicine
How this research is being cited
The 12 articles above have been cited 27 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2026 · BMC Bioinformatics
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Francisca Ba do Nascimento et al. · 2023 · Future Microbiology
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2023 · Journal of Breast Cancer
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2023 · Future Microbiology
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2021 · Nature Communications
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2021 · Frontiers in Bioengineering and Biotechnology
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2021 · Tropical Medicine and Infectious Disease
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2021 · Tropical Medicine and Infectious Disease
A sample of recent works citing this journal's research on Peptides, linking to each citing work.