Insulin secretion is the regulated release of insulin from pancreatic beta cells, the principal mechanism by which the endocrine Pancreas controls blood glucose. Glucose entering the beta cell is metabolised to raise the ATP/ADP ratio, closing ATP-sensitive potassium channels, depolarising the membrane, opening volt…
Insulin secretion is the regulated release of insulin from pancreatic beta cells, the principal mechanism by which the endocrine Pancreas controls blood glucose. Glucose entering the beta cell is metabolised to raise the ATP/ADP ratio, closing ATP-sensitive potassium channels, depolarising the membrane, opening voltage-gated calcium channels, and triggering calcium-dependent exocytosis of insulin granules. Secretion follows a characteristic biphasic pattern and is amplified by incretin hormones, nutrients and neural input, while chronic glucotoxicity, lipotoxicity and beta-cell dysfunction progressively impair it in the evolution of type 2 diabetes. Beta-cell function is evaluated through dynamic glucose challenges, measures of secretory capacity, and the interplay between secretion and peripheral insulin sensitivity, and is influenced by nutrition, body composition, hormonal milieu and pharmacological or phytotherapeutic agents. Research collected under this term addresses related metabolic themes: metabolomic bioinformatics in type 2 diabetes, dietary approaches to obesity reversal, phytotherapeutic adjuncts such as fenugreek extract in streptozotocin-induced diabetic models, surrogate-index identification of insulin-sensitive versus insulin-resistant phenotypes, cinnamon supplementation in polycystic ovary syndrome, thyroid-hormone contributions in obesity, and vitamin D status in type 2 diabetes. The peer-reviewed literature in this area examines beta-cell function, glucose-stimulated secretion and their modulation by nutrition and metabolic state in diabetes and related endocrine conditions.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 62 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Insulin Secretion, linking to each citing work.