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Apr 2020 DOI 10.14302/issn.2832-4048.jsm-20-3211
John PapaconstantinouCorresponding author
Aging mammalian skeletal muscle satellite cells (MuSCs) undergo a decline of stem cell/progenitor cell proliferative and regenerative capacity, and the development of a physiological milieu characteristic of a state of chronic sterile inflammation. p38αMAPK and ERK1/2 are two major signaling pathway…
Aug 2019 DOI 10.14302/issn.2576-6694.jbbs-19-2953
Nida Syed Amber IlyasCorresponding author
Breast cancer has high incidence in women from both developed and developing countries. Approximately 2 million women are diagnosed with breast cancer in 2018. In Asia, unfortunately Pakistan leads the highest number of breast cancer patients. Various treatment strategies are present but they are no…
Jul 2017 DOI 10.14302/issn.2639-1716.jn-17-1495
Michael J GonzalezCorresponding author
Diets high in unsaturated fatty acids, especially those containing high levels of linoleic acid, e.g., corn oil, enhance mammary gland tumorigenesis in experimental animals. In contrast, diets high in long-chain polyunsaturated fatty acids such as eicosapentaenoic (EPA) and docosahexaenoic (DHA), e.…
Mar 2014 DOI 10.14302/issn.2372-6601.jhor-13-362
Spiros A. VlahopoulosCorresponding author
A narrative review summarizes how fenofibrate influences cancer cell metabolism and proliferation. It reviews PPAR‑α–dependent and independent mechanisms, context‑specific effects, and implications for repurposing studies.
Feb 2014 DOI 10.14302/issn.2372-6601.jhor-13-346
Chloe E. ClaphamCorresponding author
Targeting cell metabolism is a therapeutic approach which has been used for the treatment of cancers with high levels of proliferation. Inhibition of metabolic processes in cancer cells has shown synergy with current therapeutic options to reduce refractory disease and relapse. In contrast, chronic…