Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing
articles matching Cancer Stem Cells — open any to read the full text,
or download the PDF or XML.
K Arora SunilCorresponding author Department of Immunopathology; Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160011, India.
A review discusses the relationship between cancer stem cells and field cancerization, considering bidirectional influences and implications for prevention and targeted therapy.
E. Geusz MichaelCorresponding author Bowling Green State University, Dept. of Biological Sciences, Bowling Green, OH 43403
Cancer is influenced by the ability of cells to maintain circadian rhythms in molecular and metabolic processes. Disturbance of the underlying circadian timing mechanism in circadian clock cells leads to a higher frequency and more rapid progression of cancer. Cancer stem cells with properties of embryonic and somatic stem cells have been implicated as tumor initiators in several types of cancers. Although tumors are reported to have disorganized circadian rhythms, evidence of in vitro circadian rhythms in cancer stem cells of gliomas was recently presented. The possibility and consequences of circadian clocks functioning in cancer stem cells within tumors is examined, and the possible benefits to these cells from circadian timing is discussed in relation to cancer treatments.