Cell lines are populations of cells, typically derived from a single founding cell, that have been adapted to grow continuously in culture, providing a clonally homogeneous and reproducible experimental system. They may be finite, with a limited number of divisions, or immortalized, having acquired the capacity for …
Cell lines are populations of cells, typically derived from a single founding cell, that have been adapted to grow continuously in culture, providing a clonally homogeneous and reproducible experimental system. They may be finite, with a limited number of divisions, or immortalized, having acquired the capacity for indefinite proliferation through spontaneous mutation, viral transformation, or deliberate introduction of immortalizing genes; many widely used lines originate from tumors and retain disease-relevant features. Because they offer a defined, scalable, and standardized substrate, cell lines are indispensable for studying gene function, signaling, and metabolism, for high-throughput drug and cytotoxicity screening, for modeling cancer and genetic disorders, and for producing recombinant proteins, antibodies, and vaccines. Their value depends on rigorous authentication and contamination control, since misidentification or genetic drift can compromise reproducibility, and on awareness that established lines may diverge from primary tissue. The journal publishes peer-reviewed research employing cell lines across cell and molecular biology, including cancer cell-line studies of epithelial-mesenchymal transition and cytotoxic nanoparticle activity, microRNA and gene-expression regulation, proteomic analyses of drug response, thyroid and colorectal cancer models, and cell-line-based biomarker assessments, illustrating the central role of defined cellular systems in mechanistic and translational investigation.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 27 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Cell Lines, linking to each citing work.