Research Topic · Peer-Reviewed

Cell Death

Cell death is the cessation of a cell's vital functions, occurring either as a tightly regulated, programmed event or as uncontrolled necrosis following severe injury. The best-characterized programmed form is apoptosis, an orderly process driven by caspase cascades through intrinsic (mitochondrial) and extrinsic (d…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 78× across the literature 🗓 Reviewed June 2026

Overview

Cell death is the cessation of a cell's vital functions, occurring either as a tightly regulated, programmed event or as uncontrolled necrosis following severe injury. The best-characterized programmed form is apoptosis, an orderly process driven by caspase cascades through intrinsic (mitochondrial) and extrinsic (death-receptor) pathways, which dismantles the cell while preserving membrane integrity to avoid inflammation. Additional regulated modalities, including necroptosis, autophagy-associated death, pyroptosis, and ferroptosis, expand the repertoire of mechanisms by which cells are eliminated. Programmed cell death is indispensable for embryonic development, tissue homeostasis, immune selection, and the removal of damaged, infected, or potentially neoplastic cells. Its dysregulation is central to disease: insufficient death permits tumor survival and autoimmunity, whereas excessive death contributes to neurodegeneration, ischemic injury, and tissue loss. Because cancer cells frequently evade apoptosis, restoring or triggering cell-death pathways, including modulation of immune checkpoints such as the programmed cell death protein-1 axis, is a major therapeutic strategy. The journal publishes peer-reviewed research in cell and molecular biology examining death pathways and their regulation, including checkpoint blockade in cancer, apoptosis and resistance in tumor cells, oxidative stress and cytoprotection in neural and cardiac cells, and the roles of cell death in carcinogenesis, metastasis, and therapy response.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 78 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cell Death, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Cell.

Journal editorial board
Faiz Ul Amin · Korea, Democratic People's Rep Yuping Li · United States Hong WAN · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.