Membrane proteins are proteins associated with biological membranes, either integrated into the lipid bilayer as integral (transmembrane) proteins or attached at the surface as peripheral proteins. They mediate essential functions including selective transport, signal transduction, cell adhesion, enzymatic catalysis…
Membrane proteins are proteins associated with biological membranes, either integrated into the lipid bilayer as integral (transmembrane) proteins or attached at the surface as peripheral proteins. They mediate essential functions including selective transport, signal transduction, cell adhesion, enzymatic catalysis, and energy transduction, and constitute the majority of pharmacological drug targets. Integral membrane proteins are classified by their topology and the number of membrane-spanning segments, commonly alpha-helical bundles or beta-barrels, while their hydrophobic surfaces present distinctive challenges for isolation, solubilization, and structural characterization. Receptors such as G-protein-coupled receptors and ion channels convert extracellular cues into intracellular responses, and receptor oligomerization, including heteromer formation, modulates signaling specificity. Methodologically the study of membrane proteins relies on affinity purification, mass spectrometry, proteomic profiling, and analysis of receptor and transporter function within native lipid environments. Research connected to this area includes isolation of monoclonal antibodies recognizing receptor heteromers, characterization of eukaryotic signature proteins, optimization of affinity purification coupled to tandem mass spectrometry, analysis of viral structural proteins, and proteomic responses to cellular stress. The journal publishes peer-reviewed work in biochemistry addressing membrane-protein structure, purification, receptor signaling, and proteomic methodology, linking the physical organization of the bilayer to molecular transport and cellular communication.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 30 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Membrane Proteins, linking to each citing work.