Research Topic · Peer-Reviewed

Lysine

Lysine is an essential α-amino acid, denoted Lys or K, bearing a positively charged ε-amino side chain that the human body cannot synthesise and must obtain from dietary protein. As a proteinogenic residue it contributes to protein structure and stability, participates in ionic interactions and substrate binding, an…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 52× across the literature 🗓 Reviewed June 2026

Overview

Lysine is an essential α-amino acid, denoted Lys or K, bearing a positively charged ε-amino side chain that the human body cannot synthesise and must obtain from dietary protein. As a proteinogenic residue it contributes to protein structure and stability, participates in ionic interactions and substrate binding, and serves as a key site for post-translational modifications such as acetylation, methylation, ubiquitination, and crosslinking. Its reactive ε-amino group makes lysine central to non-enzymatic glycation and the formation of advanced glycation end-products, in which reactions with reducing sugars and dicarbonyls such as methylglyoxal generate crosslinks and reactive oxygen species relevant to ageing and metabolic disease. The same reactivity necessitates side-chain protection strategies during solid-phase peptide synthesis, an active area of methodological development. Lysine also influences collagen formation, calcium handling, and immune function, and its availability is a determining factor in protein quality and nutrition across human and animal diets. Research in this area further examines lysine-related chemistry in food processing, including Maillard reactions and hydroxymethylfurfural formation. The journal publishes peer-reviewed research on amino-acid chemistry, metabolism, and the biochemical roles of lysine in biological and applied systems.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603
2020

pH-Sensitive Nanomedicine for Treating Gynaecological Cancers

Vishwanath Prasad PramodCorresponding author
Center for Biomedical Research, Population Council, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Exact topic Women's Reproductive Health Cited by 8 doi:10.14302/issn.2381-862X.jwrh-19-3143

How this research is being cited

The 12 articles above have been cited 52 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Lysine, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Amino Acids.

Journal editorial board
Nicolas Inguimbert · France

This page summarises published research for orientation; it is not medical or professional advice.