Clinical Epilepsy

Overview

Clinical epilepsy refers to the diagnosis, characterization, and management of epilepsy as encountered in patients, a chronic neurological disorder defined by an enduring predisposition to recurrent, unprovoked seizures arising from abnormal, excessive, and synchronous electrical activity in the brain. It is among the most common serious neurological conditions worldwide and presents with diverse seizure types and epilepsy syndromes, ranging from focal seizures originating in a localized brain region to generalized seizures involving widespread networks. Clinical practice involves distinguishing epileptic seizures from non-epileptic events, including psychogenic non-epileptic seizures that can coexist with epilepsy, as accurate classification guides treatment. Diagnosis integrates detailed history, electroencephalography, neuroimaging, and increasingly the investigation of genetic factors, since genetic polymorphisms can influence both susceptibility and response to therapy. The underlying causes are heterogeneous, encompassing structural, genetic, infectious, metabolic, immune, and unknown etiologies. Management centers on antiseizure medication selected according to seizure and syndrome type, with attention to comorbidities, drug interactions, and quality of life. For drug-resistant epilepsy, additional options include resective surgery and neuromodulation approaches such as deep brain stimulation, which targets specific brain regions to reduce seizure burden. Clinical epilepsy also addresses public understanding, attitudes, and stigma, recognizing the social as well as medical dimensions of the condition. The overarching goals are seizure control, minimization of adverse effects, and preservation of function and wellbeing.

Research published in this journal

5 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 5 articles above have been cited 19 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Strategies utilized and challenges faced by stakeholders while managing epilepsy in African schools: A scoping review
  Seth Selassie Dzah et al. · 2025 · Epilepsy & Behavior
• Strategies utilized and challenges faced by stakeholders while managing epilepsy in African schools: A scoping review
  2025 · Epilepsy & Behavior
• Closed-Loop Deep Brain Stimulation Using a Type of Fixed-Time Sliding Mode Controller for Avoiding Epileptiform Discharge in a Human Cortical Model
  2023 · Journal of Computational Biophysics and Chemistry
• Closed-Loop Deep Brain Stimulation Using a Type of Fixed-Time Sliding Mode Controller for Avoiding Epileptiform Discharge in a Human Cortical Model
  2023 · Journal of Computational Biophysics and Chemistry
• Combination of Matching Responsive Stimulations of Hippocampus and Subiculum for Effective Seizure Suppression in Temporal Lobe Epilepsy
  Fang Zhang et al. · 2021 · Frontiers in Neurology
• Cerebellar contribution to absence epilepsy
  2021 · Neuroscience Letters
• Combination of Matching Responsive Stimulations of Hippocampus and Subiculum for Effective Seizure Suppression in Temporal Lobe Epilepsy
  2021 · Frontiers in Neurology
• Cerebellar contribution to absence epilepsy
  2021 · Neuroscience Letters

A sample of recent works citing this journal's research on Clinical Epilepsy, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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