Leonardo Mastropasqua, Toto Lisa, Peter Mattei, Luca Vecchiarino, Alessandra Mastropasqua, Gennaro Falconio, Marzio Guido Di, Tissue trauma induced by lens fragmentation patterns in femtosecond laser assisted cataract surgery, Journal of Applied Robotics and Artificial Intelligence, Volume 1, Issue 1, 2017, Pages 1-9, ISSN 0000-0000, https://doi.org/. (https://oapgroup.org/jrai/article/585) Abstract: Background: To evaluate cumulative dissipated energy (CDE), laser time, central corneal thickness and endothelial cell loss after two different fragmentation pattern by means of femtosecond laser-assisted cataract surgery (FLACS). Methods: Eighty eyes of 80 patients that underwent FLACS were randomized in two groups: mixed chop and dice lens fragmentation pattern (group 1 with 40 eyes) and mixed chop and cylindrical lens fragmentation pattern (group 2 with 40 eyes). Results: Cumulative dissipated energy was significantly lower in group 1 compared to group 2 (p<0.001). Postoperatively there was a decrement of endothelial cells count at the centre of the cornea in both groups compared with preoperative values with greater decrease in Group 2 (p<0.001). The thickness at the tunnel site showed a greater increase in group 2 compared to group 1 immediately after surgery (p<0.001) The thickness measured at the center of the cornea increased slightly immediately after surgery and showed a similar decrease in both groups. The increase was greater in Group 2 (p<0.001). Conclusions: Both lens fragmentation patterns were effective in nucleus disassembly. Nevertheless dice pattern was related with a lower amount of CDE and induced lower central endothelial cell loss and lower increase of corneal thickness. Keywords: femtosecond laser-assisted cataract surgery; phacoemulsification; cumulative dissipated energy.