Ferrarini Isacco, Turri Gloria, Veneri Dino, Tecchio Cristina, Ambrosetti Achille, Immune Thrombocytopenia after Allogeneic Stem Cell Transplantation: Case Report and Brief Overview of Treatment Strategies, Journal of Hematology and Oncology Research, Volume 2, Issue 3, 2016, Pages 3-8, ISSN 2372-6601, https://doi.org/10.14302/issn.2372-6601.jhor-16-1330.
(https://oapgroup.org/jhor/article/398)
Abstract: Immune thrombocytopenia (ITP) is a rare but well-recognized post-allogeneic hematopoietic stem cell transplant (HSCT) autoimmune complication for which a standard treatment approach is lacking. Herein we report on an adult patient affected by high-risk acute myeloid leukemia (AML) who developed a post-HSCT ITP. Due to the refractoriness to first-line therapies the patient underwent the thrombopoietin (TPO) mimetic Eltrombopag obtaining the ITP resolution. We also discuss the clinical course of ITP in post-HSCT setting and pros and cons of different therapeutic strategies, focusing on the emerging role of TPO mimetics.
Keywords: ; Leukemia; Allogeneic stem cell transplantation; Immune thrombocytopenia; Eltrombopag