Salcedo Ivonne, Aguayo Alvaro, Zuñiga Javier, Syndrome of inappropriate antidiuretic hormone secretion in a patient with a Nodular Lymphocyte-Predominant Hodgkin Lymphoma. A case report and review of literature, Journal of Hematology and Oncology Research, Volume 2, Issue 1, 2015, Pages 1-6, ISSN 2372-6601, https://doi.org/10.14302/issn.2372-6601.jhor-15-657.
(https://oapgroup.org/jhor/article/188)
Abstract: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a known side effect of several oncology drugs, but it is rarely seen secondary to vinblastine with only a few cases reported worldwide. Herein we present a patient with nodular lymphocyte-predominant Hodgkin disease that developed a severe acute hyponatremia seven days after her first cycle of chemotherapy with R-ABVD. After fluid restriction, symptoms and concentration of blood sodium were restored. After a comprehensive review of the literature vinblastine was thought to be the cause and avoided in the second infusion of chemotherapy without recurrence of the SIADH.
Keywords: lymphoma; vinblastine; SIADH